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Clinical and Research Reports

Efficacy of Adjuvant High Frequency Repetitive Transcranial Magnetic Stimulation on Negative and Positive Symptoms of Schizophrenia: Preliminary Results of a Double-Blind Sham-Controlled Study

Nishant Goyal, D.P.M., S. Haque Nizamie, M.D., D.P.M. and Pushpal Desarkar, M.D., D.P.M.

Received May 30, 2006; revised June 29, 2006; accepted October 17, 2006. Drs. Goyal, Nizamie, and Desarkar are affiliated with the Adult Psychiatry Unit, Central Institute of Psychiatry, Ranchi , Jharkhand , India . Address correspondence to Dr. Desarkar, Department of Child and Adolescent Psychiatry, Central Institute of Psychiatry, Kanke (PO), Ranchi-834006, Jharkhand, India; pushpalds@yahoo.com (e-mail).


The potential effect of repetitive transcranial magnetic stimulation (rTMS) on core positive and negative symptoms in schizophrenia has not yet been clearly established. The aim of this study was to examine the efficacy of adjuvant 10 Hz, suprathreshold left prefrontal rTMS in negative symptoms of schizophrenia in a double-blind sham-controlled design. Additionally, our study also investigated the suitability of applying the same stimulus condition on positive symptoms. Ten right-handed schizophrenia patients received sham or active 10 Hz suprathreshold rTMS to the left dorsolateral prefrontal cortex with psychopathology, depression and global improvement ratings before and after rTMS sessions. Compared to sham, active rTMS significantly improved negative symptoms, irrespective of change in depressive symptoms.

Neuropsychiatry Clin Neurosci 19:464-467, November 2007
doi: 10.1176/appi.neuropsych.19.4.464
© 2007 American Psychiatric Publishing, Inc.